Whitaker International Fellow, 2014

Name: James Wade

Home Institution: Georgia Institute of Technology and Emory University (joint)

Host Country, Institution: Switzerland, University of Zurich (Zurich, Switzerland)

Project Title: Modeling and Analysis of Cell Signaling in Epithelial-Mesenchymal Transitions of Breast Cancer

Project Abstract

Dr. Bodenmiller at the University of Zurich is a leader in the field of signaling network analysis and co-developer of mass cytometry (MC). MC is a new technique that allows simultaneous measurements of many more signaling proteins in single cells than was previously possible. I propose to visit his lab to learn and perform mass cytometry experiments related to cell signaling in epithelial-mesenchymal transitions (EMT) of breast cancer. I will use the data to create and analyze computational models of signaling during EMT. The proposed research will improve our current understanding of metastasis, provide information about drug targets and pave the way toward personalized cancer treatments.


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